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Ten years ago, a mysterious spatial anomaly now known as "Heaven's Gate" appeared in South America, shortly followed by the opening of "Hell's Gate" in Tokyo altering the sky and wreaking havoc on the landscape. The real stars disappeared, replaced by false stars. During this time, people possessing various special abilities — called "Contractors" — emerged, each capable of different supernatural feats. Following the disastrous Heaven's War, the United States lost its dominant position as a superpower to a mysterious organization named the Syndicate. The story revolves around a Chinese contractor codenamed "Hei" as he undertakes various espionage and assassination missions in Tokyo.

A supernatural system allows people to take revenge by having other people sent to Hell via the services of a mysterious entity and her assistants who implement this system. Revenge, injustice, hatred, and the nature of human emotions are common themes throughout the series.

A species of parasitic aliens descends on Earth and quickly infiltrates humanity by entering the brains of vulnerable targets; insatiable beings that gain total control of their host and are capable of transforming themselves to feed on unsuspecting prey. High school student Shinichi Izumi falls victim to one of these parasites, but the creature fails to take over his brain and ends up in his right hand.

In a world where beasts of all kinds coexist, a gentle wolf awakens to his own predatory urges as his school deals with a murder within its midst.

As the result of a childhood injury, Shiki Tohno can see the lines of energy that bind all things together and by severing those lines he can destroy almost anything! Only a special pair of glasses that mute his extraordinary perceptions have kept him sane, but his attempts at living a “normal” life come to a shocking end when he is approached by a strange and dangerous woman. Now, Shiki is fighting both for his life and to unravel the secrets of his own past.

The Medicine Seller is a deadly and mysterious master of the occult who travels across feudal Japan in search of malevolent spirits called mononoke to slay. When he locates one of these spirits, he cannot simply kill it; he must first learn its Form, its Truth, and its Reason in order to wield the mighty Exorcism Sword and fight against it. He must begin his strange exorcisms with intense psychological analysis and careful investigative work—an extremely dangerous step, as he must first confront and learn about the mononoke before he even has the means to defeat it.

The story centers on Keitarou Gentouga, who has the ability to be a spirit medium. In junior high school, he got someone else wrapped up in a spirit possession incident, and he has been a shut-in for more than two years. As he reintroduces himself to society as a private tutor, he meets a genius girl named Yayoi Houzuki. Yayoi is instantly able to tell that Keitarou has skill as a spirit medium, and she invites him to go with her to a haunted location. The two then start their journey capturing evil spirits.

Shy Natsu awakens as part of a group chosen to ensure the survival of humanity. Together, they have to survive on a changed Earth.

When lone swordsman Guts is defeated in a duel by Griffith, ambitious leader of the Band of the Hawk mercenaries, he now must fight for him. Distrustful of all at first, through hard-fought battles, he soon begins to bond with his new comrades and their leader. As they rise in rank to a full-fledged army, he begins to harbor doubts about a life lived by the blade, unaware a dreadful fate that awaits.

Sotobamura is a small village with around 1300 residents; so small the village isn't even connected to a single highway. An isolated village in which old customs, such as the burial of the dead, are still practiced. One day, the bodies of three people are found dead. Although Ozaki Toshio, the village's lone doctor, feels uncertain, he treats the deaths as a normal occurrence. However, in the days following, the villagers start to die one after the other.

Ai, a young girl with shut-in tendencies, who tries not to interact with others. She keeps one of her eyes hidden behind her hair. One day, she happens to stop by a deserted arcade, where she meets "Aka." Spinning the gacha at their urging, she acquires a "Wonder Egg," and from that moment, her fate begins to change...

Sato is a high school boy in love with his best friend Hime, an unearthly beauty from another realm. So when she moves back to her home world to get married, Sato doesn’t think twice—he follows her and crashes the wedding. Then, after a kiss from Hime, he suddenly becomes the new groom! But here, Hime is a Ring Princess and her husband is destined to be the Ring King: a hero of immense power.

Ginko, a Mushi master, travels from place to place researching the Mushi and helping people who are suffering because of it.

Kenzou Tenma, a Japanese brain surgeon in Germany, finds his life in utter turmoil after getting involved with a psychopath that was once a former patient.

The story follows Justice Akazuka (a.k.a. Seigi), a young man who is good at martial arts. One day, Seigi rescues a homeless old man from some thugs, and the man gives him an object that imprints a tattoo on his palm. However, it is not an ordinary tattoo, but a special weapon that gives Seigi supernatural powers such as warping space-time. Seigi then meets a female American agent named Izzie, whose duty is to recover the tattoos. He decides to help her and gets wrapped up in a cross-national conspiracy.

Kasugano Haruka and his sister Sora have lost both their parents in an accident, and with them all their support. They decide to move out of the city to the rural town where they once spent summers with their late grandfather. At first everything seems familiar and peaceful, but changes come as Haruka starts to remember things from his youth.

Sakaido is a genius detective who can track down any criminal. But when his daughter is murdered, revenge lands him on the other side of the law. Now in prison, he helps the police solve mysteries using a system that invades a person’s identity. Little by little, a trail of blood forms, and it all leads back to his daughter’s murderer.

Spurred by the flame raging in his heart, the Black Swordsman Guts continues his seemingly endless quest for revenge. Standing in his path are heinous outlaws, delusional evil spirits, and a devout child of god. Even as it chips away at his life, Guts continues to fight his enemies, who wield repulsive and inhumane power, with nary but his body and sword—his strength as a human.